An oncolytic adenoviral vector carrying the tyrosinase promoter for glioma gene therapy
نویسندگان
چکیده
منابع مشابه
An oncolytic adenoviral vector carrying the tyrosinase promoter for glioma gene therapy.
Targeting gene expression to cancer cells remains a challenge for the development of gene and viral therapy for gliomas. Recent studies have highlighted transcriptional targeting as one of the possible solutions to overcome this limitation. In this context, melanoma associated antigens (MAAs) are usually over-expressed in brain tumors in comparison to normal brain tissue. For this reason, we in...
متن کاملAdenoviral vector systems for gene therapy
Adenoviral (Ad) vectors are widely used in gene therapies, recombinant viral vaccines, and basic science studies. The vectors can deliver therapeutic genes into cells to recover the lost function of some genes, to enhance the ability of host immune systems, or to increase the sensitivity of cancer cells to chemotherapeutic drugs. Several adenoviral vector systems have been developed: first-gene...
متن کاملConstruction of recombinant adenoviral vector carrying cyclinA2 gene.
Cell cycle related molecules in mammalian cochleae could provide a new avenue to restore hearing loss caused by a variety of genetic and environmental insults. CyclinA2 is one of the most important regulators of cell cycle, but its role in the mammalian cochlea is still unknown. So, it is necessary to construct an adenovirus vector carrying cyclinA2 gene for clarifying its function in the cochl...
متن کاملAdenoviral vector-mediated gene transfer for human gene therapy.
Human gene therapy promises to change the practice of medicine by treating the causes of disease rather than the symptoms. Since the first clinical trial made its debut ten years ago, there are over 400 approved protocols in the United States alone, most of which have failed to show convincing data of clinical efficacy. This setback is largely due to the lack of efficient and adequate gene tran...
متن کاملA new oncolytic adenoviral vector carrying dual tumour suppressor genes shows potent anti-tumour effect
Cancer Targeting Gene-Viro-Therapy (CTGVT) is a promising cancer therapeutical strategy that strengthens the anti-tumour effect of oncolytic virus by expressing inserted foreign anti-tumour genes. In this work, we constructed a novel adenoviral vector controlled by the tumour-specific survivin promoter on the basis of the ZD55 vector, which is an E1B55KD gene deleted vector we previously constr...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: International Journal of Oncology
سال: 2007
ISSN: 1019-6439,1791-2423
DOI: 10.3892/ijo.31.5.1177